Phenoxy compounds

Medchemexpress LLC 4H-1-Benzopyran-4-one, 6-methoxy-5-nitro-2-(trifluoromethyl)- | 342795-08-8 | 99.85% | 289.16 | 50 MG

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Bragsin2 is a potent, selective, and noncompetitive nucleotide exchange factor BRAG2 inhibitor with an IC50 of 3 μM. It binds at the interface between the PH domain of BRAG2 and the lipid bilayer, preventing activation of lipidated Arf GTPase. This compound affects breast cancer stem cells.

• Potent, selective, and noncompetitive nucleotide exchange factor BRAG2 inhibitor with an IC50 of 3 μM.
• Binds at the interface between the PH domain of BRAG2 and the lipid bilayer.
• Leads to BRAG2 being unable to activate lipidated Arf GTPase.
• Affects breast cancer stem cells.
• Inhibits Arf GTPase activation in HeLa cells at 50 μM.
• Inhibits the growth of SUM149 and S68 cells at 50 μM.

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Medchemexpress LLC FR194738 | 204067-52-7 | 99.8% | 476.11 | C27H38ClNO2S | 25 MG

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FR194738 is a small-molecule squalene epoxidase inhibitor for preclinical research. It inhibits squalene epoxidase activity in HepG2 cell homogenates (IC50 = 9.8 nM) and is provided with analytical characterization suitable for biochemical and cellular studies.

• Potent squalene epoxidase inhibitor (IC50 = 9.8 nM).
• Suitable for biochemical and cell-based assays.
• High purity appropriate for analytical applications (~99.8%).
• Characterized by CAS number 204067-52-7 and molecular weight 476.11.
• Available in multiple vial sizes, including 25 mg.
• Supplied with supporting documentation: datasheet, COA, SDS, H NMR, LCMS.

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Medchemexpress LLC HY-15009 5mg Medchemexpress, Fuscoside CAS:131631-89-5 Purity:>98%

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Medchemexpress, HY-15009 5mg Fuscoside CAS:131631-89-5 Fuscoside (OPC-21268) is an orally effective, nonpeptide, vasopressin V1 receptor antagonist with an IC50 of 0.4 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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Medchemexpress LLC Lyp-1 tfa | 99.52% | 1106.16 | 5 MG

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LyP-1 TFA is a cyclic 9 amino acids tumor homing peptide that selectively binds to p32 receptors which are overexpressed in various tumor-associated cells. For research use only, not for sale to patients.

• Shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group (in vivo studies).
• Higher apoptotic rate in macrophages released from hypoxic plaques observed after LyP-1 treatment compared to control peptide (in vivo studies).
• Can be labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.
• Exhibits lymphatics-specific binding.

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Medchemexpress LLC HY-N0635 5mg Medchemexpress, Prim-O-glucosylcimifugin CAS:80681-45-4 Purity:>98%

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Medchemexpress, HY-N0635 5mg Prim-O-glucosylcimifugin CAS:80681-45-4 Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of iNOS and COX-2 expression by through regulating JAK2/STAT3 signaling. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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Medchemexpress LLC GNE-371 | 1926986-36-8 | 98.1% | 431.49 | 50 MG

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GNE-371 is a potent and selective chemical probe designed for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like. It demonstrates an IC50 of 10 nM for TAF1(2).

• Potent and selective chemical probe for TAF1(2).
• Binds TAF1(2) with an IC50 of 10 nM.
• Maintains excellent selectivity over other bromodomain-family members.
• Active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM).
• Exhibits anti-proliferative synergy with the BET inhibitor JQ1.
• Useful for mechanistic and target-validation studies.

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Medchemexpress LLC GNE-371 | 1926986-36-8 | 98.06% | 431.49 | 100 MG

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GNE-371 is a potent and selective chemical probe designed to target the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like. It demonstrates an IC50 of 10 nM for TAF1(2).